Tyrosine phosphorylation of phospholipase C induced by membrane immunoglobulin in B lymphocytes.
نویسندگان
چکیده
منابع مشابه
Activation of Phospholipase C 2 by Tyrosine Phosphorylation
Phospholipase C 2 (PLC 2) has been implicated in collageninduced signal transduction in platelets and antigen-dependent signaling in B-lymphocytes. It has been suggested that tyrosine kinases activate PLC 2. We expressed the full-length cDNA for human PLC 2 in bacteria and purified the recombinant enzyme. The recombinant enzyme was Ca -dependent with optimal activity in the range of 1 to 10 M C...
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The link between IL-13 and bronchial hyper-responsiveness has brought this cytokine as a potential therapeutic target for asthma and allergic diseases. At the present study, we address the role of B cell derived IL-13 in the IgE and other immunoglobulin development. Antisense oligo for human IL-13 m-RNA was used to study IgE down regulation. Human B-lymphocytes were purified by positive selecti...
متن کاملTyrosine phosphorylation regulates phospholipase C activation in human T-cells.
Introduction One early transmembrane signal in response to stimulation of the T-cell antigen receptor (CD 3/Ti) is the activation of phosphatidylinositol (Ptd1ns)specific phospholipase C (PLC). The resulting formation of inositol 1,4,5-trisphosphate (Ins( 1,4,5)q?) and diacylglycerol (DAG) causes calcium release from internal stores, calcium influx through calcium channels, and translocation of...
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I78 are their ligands. Whether some PTPs function as anti-oncogenes by opposing the action of transforming PTKs is another important issue under active investigation. The identification of physiological substrates for each of the PTPs is a third area of research that will provide insight into the role of PTPs in signal transduction. What seems to be certain is that work over the next few years ...
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Surface IgM (sIgM) stimulation induces the tyrosine phosphorylation of multiple cellular substrates, including phospholipase C (PLC)-gamma 2, which is involved in the activation of phosphatidylinositol pathway. DT40 B cells underwent apoptotic cell death when activated through sIgM, a phenomenon that is related to elimination of self-reactive B cells. To examine the roles of PLC-gamma 2 in sIgM...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1991
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.88.7.2745